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Melt In Your Mouth Baked Chicken Breast Casserole

This Melt In Your Mouth Baked Chicken Breast Casserole is a perfect blend of tender chicken, creamy sauce, and a golden, crispy topping that will have you coming back for seconds. It’s a breeze to make, combining simple ingredients to create a comfort food dish that’s sure to impress. Whether you’re making it for a busy weeknight or serving it to guests, this casserole is easy, flavorful, and satisfying. With just a few tweaks, you can make it your own—whether you like it cheesy, spicy, or veggie-packed, this recipe will always be a hit!
Prep Time 15 minutes
Cook Time 30 minutes
Total Time 45 minutes
Servings 6
Calories 380 kcal

Ingredients
  

Ingredients for Melt In Your Mouth Baked Chicken Breast Casserole

  • Here’s everything you’ll need to make this delicious casserole:
  • 4 boneless skinless chicken breasts
  • 1 cup sour cream can substitute with Greek yogurt for a lighter version
  • 1 can cream of chicken soup or use a homemade version if preferred
  • 1 cup shredded cheddar cheese feel free to use mozzarella or a cheese blend
  • 1/2 cup breadcrumbs Panko works great for extra crunch
  • 1/4 cup melted butter
  • 1 tsp garlic powder
  • 1 tsp onion powder
  • Salt and pepper to taste

Key Substitutions:

  • If you’re not a fan of sour cream Greek yogurt is a great swap!
  • You can use any cheese you love – Parmesan or Gouda would also work well for a different twist.
  • Want it gluten-free? Use gluten-free breadcrumbs or skip them entirely for a softer top.

Instructions
 

How to Cook the Melt In Your Mouth Baked Chicken Breast Casserole: A Step-by-Step Guide

  • Let’s get cooking! This recipe is super simple, and I promise you’ll have dinner ready in no time. Follow these steps, and you’ll have a casserole that’s so good, you’ll be asking yourself why you didn’t make it sooner.

Step 1: Preheat your oven

  • Set your oven to 350°F (175°C). This is like the warm-up before a big show. Get that oven hot and ready for the magic!

Step 2: Prepare the chicken

  • Season your chicken breasts with salt, pepper, garlic powder, and onion powder. Don’t be shy with the seasoning – we want this chicken full of flavor! Place them in a baking dish.

Step 3: Mix the creamy goodness

  • In a bowl, combine the sour cream, cream of chicken soup, and cheddar cheese. Give it a good stir until everything is smooth and creamy. This is the secret sauce that makes this casserole so irresistible!

Step 4: Pour the creamy mixture over the chicken

  • Spread that creamy goodness evenly over the chicken breasts. Don’t rush it – make sure each piece is covered, like giving your chicken a nice, cozy blanket. 🛏

Step 5: Add the crunchy topping

  • Mix your breadcrumbs with the melted butter and sprinkle this crunchy topping over the casserole. This is the part where the magic happens – it’ll give your dish a golden, crispy finish.

Step 6: Bake it

  • Pop the casserole in the oven for about 30-35 minutes. While it’s baking, kick back, relax, and maybe go check out that pile of dishes you’ve been avoiding. 😉 When the chicken is cooked through and the top is golden brown, it’s ready to go!

Step 7: Serve and enjoy

  • Let it cool for a couple of minutes, then cut into it. You’ll get that perfect bite of juicy chicken and creamy sauce. Serve it up with your favorite veggies, and you’ve got yourself a meal that’s about to become a family favorite!
  • That’s it! You’ve just made the Melt In Your Mouth Baked Chicken Breast Casserole – simple, tasty, and totally satisfying. Enjoy!

Notes

  • You can swap chicken breasts for thighs if you prefer a juicier, richer taste.  
  • Use Panko breadcrumbs for a crispier, lighter topping.  
  • To make it ahead, assemble the casserole, cover, and store in the fridge for up to 24 hours before baking.

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